Name | bradykinin fragment 1-7 |
Synonyms | RPPGFSP BRADYKININ (1-7) BRADYKININ 1-7 ACETATE BRADYKININ FRAGMENT 1-7 bradykinin fragment 1-7 ARG-PRO-PRO-GLY-PHE-SER-PRO ARG-PRO-PRO-GLY-PHE-SER-PRO ACETATE H-ARG-PRO-PRO-GLY-PHE-SER-PRO-OH ACOH H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Oh Acetate Salt H-ARG-PRO-PRO-GLY-PHE-SER-PRO-OH ACETATE SALT |
CAS | 23815-87-4 |
InChI | InChI=1/C35H52N10O9/c36-22(10-4-14-39-35(37)38)31(50)44-16-6-12-26(44)33(52)43-15-5-11-25(43)30(49)40-19-28(47)41-23(18-21-8-2-1-3-9-21)29(48)42-24(20-46)32(51)45-17-7-13-27(45)34(53)54/h1-3,8-9,22-27,46H,4-7,10-20,36H2,(H,40,49)(H,41,47)(H,42,48)(H,53,54)(H4,37,38,39)/t22-,23-,24-,25-,26-,27-/m0/s1 |
Molecular Formula | C35H52N10O9 |
Molar Mass | 756.85 |
Density | 1.52g/cm3 |
Water Solubility | Soluble in water (1 mg/ml). |
Appearance | White freeze-dried powder |
Storage Condition | −20°C |
Refractive Index | 1.695 |
MDL | MFCD00076262 |
In vitro study | The Bradykinin peptide system is a tissue-based system with potent cardiovascular and renal effects. To investigate the regulation of this system, a highly sensitive amino terminal-directed radioimmunoassay that, with high performance liquid chromatography, enables the measurement of Bradykinin-(1-7), Bradykinin-(1-8), and Bradykinin-(1-9), is developed. Together with a carboxy terminal-directed radioimmunoassay, Bradykinin peptides in rat kidney and blood are characterized. The predominant Bradykinin peptides in kidney are Bradykinin-(1-9) (~100 fmol/g wet weight of tissue) and Bradykinin-(1-7) (~70 fmol/g), with low levels of Bradykinin-(1-8) (~8 fmol/g) and Bradykinin-(4-9) (~12 fmol/g) detectable; Bradykinin-(2-9) and Bradykinin-(3-9) are below the limits of detection. In blood, the levels of Bradykinin-(1-9) are very low (~2 fmol/ml), and other Bradykinin peptides are below the limits ofdetection. Administration of the angiotensin converting enzyme (ACE) inhibitor Perindopril is associated with an approximate twofold increase in renal levels of Bradykinin-(1-8) and Bradykinin-(1-9) and a decrease in the Bradykinin-(1-7)/Bradykinin-(1-9) ratio. The amino terminal-directed radioimmunoassay is also applied to heart, aorta, brown adipose tissue, adrenal, lung, and brain. For these tissues, Bradykinin-(1-7) and Bradykinin-(1-9) are of similar abundance (16-340 fmol/g), with lower levels of Bradykinin-(1-8). |
WGK Germany | 3 |
biological activity | Bradykinin (1-7) is an amino truncated kinin peptide. Bradykinin (1-7) is a Bradykinin metabolite formed by endopeptidase cleavage. |